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  • Title: [Effects of levodopa and piribedil on cyclic AMP levels in cerebrospinal fluid in rats (author's transl)].
    Author: Cramer H, Kiessling M.
    Journal: Arzneimittelforschung; 1976; 26(6):1106-7. PubMed ID: 183794.
    Abstract:
    30 min after injection of levodopa (200 mg/kg) into rats the cAMP levels in the cisternal fluid were significantly elevated by 60% over controls. When dopamine-beta-hydroxylase was inhibited by bis-(4-methyl-1-homopiperazinyl-thiocarbonyl)-disulfide (Fla 63) the levodopa induced increase of cAMP levels was less marked, it was suppressed by propranolol (10 mg/kg), a beta-adrenergic blocking agent. Piribedil (10 mg/kg) failed to influence cisternal cAMP concentrations. The findings do not support the concept of a dopamine-sensitive adenylate cyclase in vivo, and suggest a beta-adrenergic stimulation of cerebral adenylate cyclase by metabolites of levodopa.
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