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  • Title: [Effect of molsidomine infusion on thrombocyte function in acute myocardial infarct].
    Author: Hiller E, Fischer U, von Essen R, Riess H.
    Journal: Z Kardiol; 1991; 80 Suppl 5():59-62. PubMed ID: 1837969.
    Abstract:
    In 10 patients with acute myocardial infarction i.v. molsidomine was given over 48 h and a number of platelet functions was evaluated before and 3, 24, and 48 h after therapy. There was a significant prolongation of template bleeding time from 290 s to 400 s. The amplitude of spontaneous and induced platelet aggregation remained unchanged. In four of the 10 patients initially high plasma concentrations of beta-TG and PF4, and high serum concentrations of TxB2, decreased, indicating an effect of molsidomine in states of hyperreactive platelets.
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