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  • Title: [Insights in the central serotonergic function in patients with affective disorders].
    Author: Kawohl W, Hegerl U, Müller-Oerlinghausen B, Juckel G.
    Journal: Neuropsychiatr; 2008; 22(1):23-7. PubMed ID: 18381053.
    Abstract:
    OBJECTIVE: The simple insight in the central serotonergic activity would allow a more specific pharmacotherapy of disorders with serotonergic deficits and could thus serve as a predictive parameter. An antidepressive treatment could be chosen due to the verification or falsification of such a deficit with a serotonergic or noradrenergic substance. In search of predictive parameters we have investigated the loudness dependence of auditory evoked potentials (LDAEP), a parameter that has already been discussed concerning this matter, and serotonin levels in the human blood serum regarding their correlation. METHODS: Eight outpatients of a lithium clinics were investigated neurophysiologically after blood samples had been taken. RESULTS: A significant negative correlation between LDAEP and serotonin level in the serum was found, a low serotonin level correlates with a high LDAEP. CONCLUSIONS: The result of this pilot study justifies further investigations with larger sample sizes. In case of further and stable evidence the use of serotonin levels in the serum as a predicitve parameter is conceivable.
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