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  • Title: Complexation study of midazolam hydrochloride with beta-cyclodextrin: NMR spectroscopic study in solution.
    Author: Ali SM, Upadhyay SK.
    Journal: Magn Reson Chem; 2008 Jul; 46(7):676-9. PubMed ID: 18381674.
    Abstract:
    (1)H NMR spectroscopic study of midazolam hydrochloride (MDL), beta-cyclodextrin (beta-CD) and their mixtures confirmed the formation of beta-CD-MDL inclusion complex in aqueous solution. The stoichiometry of the complexes was determined by Scott's method to be 1:1, and the association constant (K(a)) was calculated to be 108 M(-1). It was confirmed on the basis of 2D ROESY spectral data that only a fluorine-substituted aromatic ring acted as guest in complexation. Most of the aromatic signals of MDL exhibited induced shift changes as well as splitting, in the presence of beta-CD, indicating chiral differentiation of MDL by beta-CD.
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