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  • Title: Multichannel surface recordings on the visual cortex: implications for a neuroprosthesis.
    Author: Chelvanayagam DK, Vickery RM, Kirkcaldie MT, Coroneo MT, Morley JW.
    Journal: J Neural Eng; 2008 Jun; 5(2):125-32. PubMed ID: 18382049.
    Abstract:
    Using a multi-channel platinum surface electrode array, recordings from cat primary visual cortex were obtained in response to visual stimuli, and electrical stimuli delivered using the elements of the array itself. Neural responses to electrical stimuli were consistent, regardless of stimulus polarity or leading phase (biphasic), although thresholds were lower for monophasic than biphasic pulses. Both visual and electrical stimuli reliably evoked responses with characteristic components, which interacted with each other in a nonlinear summation showing first facilitation then suppression during the window of interaction. The chronaxie for eliciting threshold cortical responses was about 100 mus, and the charge density with a pulse width of 50-100 mus was around 55 muC cm(-2). These data form the basis of understanding the types of cortical responses to stimuli delivered by devices suitable for chronic implantation.
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