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  • Title: Increased plasma leptin in antipsychotic-naïve females with schizophrenia, but not in males.
    Author: Wang HC, Yang YK, Chen PS, Lee IH, Yeh TL, Lu RB.
    Journal: Neuropsychobiology; 2007; 56(4):213-5. PubMed ID: 18382119.
    Abstract:
    BACKGROUND: Metabolic abnormalities, including insulin resistance and increased leptin levels, were noted in patients with schizophrenia who had received antipsychotics. In this study, we examined the leptin levels of antipsychotic-naïve schizophrenic patients. METHOD: Seventeen antipsychotic-naïve patients with schizophrenia and 16 sex-, age- and body mass index (BMI)-matched subjects were recruited from the psychiatric outpatient clinic and community, respectively. Serum leptin levels of the healthy controls and antipsychotic-naïve patients were compared. The relationships between leptin level and gender, Positive and Negative Syndrome Scale score, and duration of illness were analyzed by Spearman's correlation. RESULTS: Compared with sex-, age- and BMI-matched subjects, the female schizophrenic patients had elevated serum leptin levels. In the male patients, the results of this preliminary study also revealed a positive correlation between leptin levels and the Aggression Risk Profile subscale of the PANSS. CONCLUSION: This preliminary study suggests possible gender-specific leptin dysregulation in antipsychotic-naïve schizophrenic patients.
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