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  • Title: Selenoprotein synthesis: an expansion of the genetic code.
    Author: Böck A, Forchhammer K, Heider J, Baron C.
    Journal: Trends Biochem Sci; 1991 Dec; 16(12):463-7. PubMed ID: 1838215.
    Abstract:
    A number of enzymes employ the unusual amino acid selenocysteine as part of their active site because of its high chemical reactivity. Selenocysteine is incorporated into these proteins co-translationally: biosynthesis occurs on a specific tRNA and insertion into a growing polypeptide is directed by a UGA codon in the mRNA. In E. coli, this requires a specific translation factor. Selenocysteine thus represents a unique expansion of the genetic code.
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