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  • Title: Thalamus surface shape deformity in obsessive-compulsive disorder and schizophrenia.
    Author: Kang DH, Kim SH, Kim CW, Choi JS, Jang JH, Jung MH, Lee JM, Kim SI, Kwon JS.
    Journal: Neuroreport; 2008 Apr 16; 19(6):609-13. PubMed ID: 18382272.
    Abstract:
    The authors performed a three-dimensional shape deformation analysis to clarify the various patterns of specific thalamic nuclei abnormality using three age-matched and sex-matched groups of 22 patients with obsessive-compulsive disorder (OCD), 22 patients with schizophrenia and 22 control participants. Compared with the healthy volunteers, the anterior, lateral outward surface deformities of the thalamus were significant in OCD patients, whereas the posterior, medial outward deformities of the thalamus were prominent in schizophrenia patients. In terms of thalamic asymmetry, both OCD and schizophrenia patients exhibited the loss of a leftward pattern of asymmetry on the posterior, medial surface of the thalamus. Different patterns of shape abnormality of specific thalamic nuclei may be related to the different phenomenology of OCD and schizophrenia.
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