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  • Title: Naphthoxazepine inhibitors of HIV-1 integrase: synthesis and biological evaluation.
    Author: Garofalo A, Grande F, Brizzi A, Aiello F, Dayam R, Neamati N.
    Journal: ChemMedChem; 2008 Jun; 3(6):986-90. PubMed ID: 18383063.
    Abstract:
    Two sets of compounds derived from the fusion of a diversely annulated naphthoxazepinedione system with 1,3-thiazole and 1,3-oxazole are described. These compounds are close analogues of previously reported thiazolothiazepine inhibitors of human immunodeficiency virus type 1 integrase (HIV-1 IN). Some of the new derivatives show potency similar to that of the reference compounds, thus gaining further insight into the structure-activity relationship of this class of IN inhibitors.
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