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  • Title: Transfusion-related acute lung injury following intravenous anti-D administration in an adolescent.
    Author: Berger-Achituv S, Ellis MH, Curtis BR, Wolach B.
    Journal: Am J Hematol; 2008 Aug; 83(8):676-8. PubMed ID: 18383320.
    Abstract:
    Transfusion-related acute lung injury (TRALI) is associated with administration of all plasma containing blood products. We present a 14-year-old adolescent diagnosed with idiopathic thrombocytopenic purpura who developed acute respiratory insufficiency compatible with TRALI within 5 hr following intravenous anti-D. Full blown noncardiogenic pulmonary edema was noted after 9 hr. Mechanical ventilation was not required and the patient made a full recovery after 36 hr. Analysis of the anti-D preparation revealed reactivity against the neutrophil FcgammaRIIIb. A postinfusion serum sample contained antibodies against class I human HLA-A11 antigen. Clinicians should consider TRALI in patients developing unexplained dyspnea after receiving intravenous anti-D.
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