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  • Title: Osteosarcoma of the head and neck region: lessons learned from a single-institution experience of 50 patients.
    Author: Laskar S, Basu A, Muckaden MA, D'Cruz A, Pai S, Jambhekar N, Tike P, Shrivastava SK.
    Journal: Head Neck; 2008 Aug; 30(8):1020-6. PubMed ID: 18383528.
    Abstract:
    BACKGROUND: Osteosarcoma of the head and neck region is a rare tumor and is a therapeutic challenge because of its aggressive nature and complex anatomical location. Standard management guidelines are lacking due to paucity of published data. METHODS: Fifty patients with head and neck osteosarcoma treated at our institute from 1995 to 2004 were reviewed. RESULTS: There were 32 men and 18 women (median, 30 years). Mandible (56%) was the most common site. Chondroblastic (46%) was the most common histopathological variant. Treatment comprised multimodality approach using surgery (100%), radiotherapy (36%), and chemotherapy (58%). After a median follow-up of 16.6 months, 46% were alive and disease free. Median overall survival was 45.7 months, and progression-free survival was 13.7 months. Mandible and maxilla were favorable sites. Postoperative adjuvant radiotherapy improved local control in patients with adverse prognostic factors. CONCLUSIONS: Surgery remains the mainstay of the treatment of head and neck osteosarcoma. Adjuvant radiotherapy improves outcome in patients with adverse factors.
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