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  • Title: Multicentre study with a new biphasic oral contraceptive containing ethinylestradiol and desogestrel. Report on efficacy, cycle control and adverse experiences with special emphasis on blood pressure and weight.
    Author: Dieben TO, van Beek A, Coelingh Bennink HJ.
    Journal: Arzneimittelforschung; 1991 Sep; 41(9):996-8. PubMed ID: 1839126.
    Abstract:
    In a multicentre study 882 women were treated during a total of 12850 cycles with a new biphasic oral contraceptive: CTR 24. The study period was 18 cycles. The biphasic preparation CTR 24 contains 25 micrograms desogestrel (CAS 54024-22-5) plus 40 micrograms ethinylestradiol (CAS 57-63-6) daily for the first 7 days followed by the combination of 125 micrograms desogestrel and 30 micrograms ethinylestradiol daily for the subsequent 15 days. One pregnancy occurred. The woman had forgotten one tablet on Day 6 of Cycle 12. The Pearl Index was 0.1 (0.0-0.5) for patient failure. The combination had a good cycle control and only few side effects were reported. In a multicenter study, 882 women were treated during a total of 12,850 cycles with a new biphasic oral contraceptive (OC) CTR 24. The study period extended for 18 cycles. This biphasic OC contains 25 mcg desogestrel (CAS 54024-22-5) + 40 mcg ethinyl estradiol (CAS 57-63-6) daily for the 1st 7 days followed by a combination of 125 mcg desogestrel and 30 mcg ethinyl estradiol daily for the subsequent 15 days. 1 pregnancy occurred in a woman who had forgotten 1 tablet on day 6 of cycle 12. The Pearl Index was 0.1 (0.0-0.5) for patient failure. The combination thus had good cycle control and only a few side effects were reported. (author's modified)
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