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  • Title: [Radioimmunoimaging of nude mice bearing human lung adenocarcinoma xenografts after injecting 131I-McAbs].
    Author: Liu L.
    Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao; 1991 Oct; 13(5):363-6. PubMed ID: 1839256.
    Abstract:
    Monoclonal antibodies (Lc86a-C5, Lc86a-H8) directed against human lung adenocarcinoma cell line LTEP-a-2 and normal BALB/c IgG were labelled with iodine-131 by chloramine T. The 131I-McAbs and 131I-IgG were respectively injected into the peritoneal cavities of nude mice bearing transplanted human lung adenocarcinoma cell line LTEP-a-2. After 72 h, the tumor tissue in nude mice injected with 131I-McAbs was distinguishable from normal tissues as a very clear image obtained during gamma scintigraphy. No difference was found between tumor and normal tissues in the nude mice injected with 131I-IgG. The tumor: blood ratio was 3.1:1 in nude mice injected with 131I-McAb(H8) and 0.9:1 in nude mice injected with 131I-IgG respectively. This indicates that the tumor tissue image was the result of specific binding of the 131I-McAbs, which have high specificity and affinity both in vitro and in vivo, to tumor cells, and these monoclonal antibodies may serve as potential agents in tumor diagnosis and treatment.
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