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  • Title: [A case of cutaneous extramedullary hematopoiesis associated with idiopathic myelofibrosis].
    Author: Corella F, Barnadas MA, Bordes R, Curell R, Espinosa I, Vergara C, Alomar A.
    Journal: Actas Dermosifiliogr; 2008 May; 99(4):297-300. PubMed ID: 18394406.
    Abstract:
    Cutaneous extramedullary hematopoiesis is a rare manifestation of chronic myeloproliferative processes, mainly chronic idiopathic myelofibrosis. In adults, it manifests as macules, papules, nodules, and ulcers on the trunk. The lesions usually appear soon after diagnosis and the possibility of a relationship between splenectomy and the appearance of extramedullary foci of hematopoiesis is still debated. Diagnosis is based on histopathology showing an infiltrate with different combinations of myeloid and erythroid cell precursors and megakaryocytes. Symptomatic treatment is provided alongside treatment of the underlying disease. We report a new case associated with chronic idiopathic myelofibrosis in which foci of cutaneous extramedullary hematopoiesis were observed 9 years after initial diagnosis. The lesions were progressive and the patient went on to develop acute myeloid leukemia.
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