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  • Title: [The activity of cationic adenosine triphosphatases in the erythrocyte membranes of patients with chronic glomerulonephritis in the preazotemia stage].
    Author: Rakhov DA.
    Journal: Ter Arkh; 1991; 63(10):147-9. PubMed ID: 1839581.
    Abstract:
    Activity of Mg-; Ca-, Na, K-ATPases of the erythrocytic membrane was studied in 67 adult patients with chronic glomerulonephritis (CGN) in the preazotemic stage and in 34 healthy persons. A significant reduction of Ca-ATPase activity was revealed, most pronounced in patients with the hypertensive and combined variants of CGN. Na, K-ATPase activity tended towards decline in all the patients. The rise of the initially decreased activity of Ca- and Na, K-ATPases was demonstrated in patients with the nephrotic variant of CGN treated with glucocorticosteroids. The decline of ATPase activity is related to the damage of cellular membranes in CGN in the preazotemic stage of the disease, which requires the carrying out of active membrane-stabilizing therapy.
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