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  • Title: The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function.
    Author: Shevach EM, Tran DQ, Davidson TS, Andersson J.
    Journal: Eur J Immunol; 2008 Apr; 38(4):915-7. PubMed ID: 18395859.
    Abstract:
    Stimulation of mouse CD4+ T cells in the presence of TGF-beta results in the expression of Foxp3 and induction of Treg function. Stimulation of human CD4+ T cells under similar conditions results in the expression of Foxp3, but the cells lack regulatory cell function. TGF-beta expressed on the surface of Treg also induces Foxp3 expression and Treg function in responder cells. Both of these mechanisms may play a role in vivo in the induction of antigen-specific extra-thymic Treg.
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