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  • Title: Piribedil in Parkinson's syndrome: a clinical study.
    Author: Engel J, Granerus AK, Svanborg A.
    Journal: Eur J Clin Pharmacol; 1975 Apr 04; 8(3-4):223-6. PubMed ID: 183960.
    Abstract:
    The effect of a new dopamine receptor stimulating agent, piribedil (ET 495), was studied in 10 patients with Parkinson's syndrome, who had had no or a poor response to previous L-DOPA treatment, or had displayed marked side effects during L-DOPA administration. Piribedil produced significant improvement of the functions of activity of daily living (ADL), and appeared to have a preferential effect on parkinsonian tremor. However, treatment was difficult to control primarily because of severe psychiatric side effects.
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