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  • Title: Mucinous tubular and spindle cell carcinoma with aggressive histomorphology--a sarcomatoid variant.
    Author: Pillay N, Ramdial PK, Cooper K, Batuule D.
    Journal: Hum Pathol; 2008 Jun; 39(6):966-9. PubMed ID: 18400251.
    Abstract:
    Mucinous tubular and spindle cell carcinoma (MTSCC) is a recently described renal epithelial tumor. The bland cytomorphology of the spindled component and low-grade behavior help in its differentiation from sarcomatoid renal carcinoma. Sarcomatoid change has been reported in most histologic variants of renal cell carcinoma apart from MTSCC. Herein we report a case of an MTSCC in a 72-year-old female patient with high-grade spindled areas resembling fibrosarcomatous and undifferentiated pleomorphic sarcoma patterns with metaplastic bone. This index case also demonstrates a high proliferation index and extensive necrosis representing the first documented case of sarcomatoid change in MTSCC.
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