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  • Title: Elevated lipoprotein(a) levels in renal transplantation and hemodialysis patients.
    Author: Heimann P, Josephson MA, Fellner SK, Thistlethwaite JR, Stuart FP, Dasgupta A.
    Journal: Am J Nephrol; 1991; 11(6):470-4. PubMed ID: 1840233.
    Abstract:
    Hyperlipidemia poses a risk for cardiovascular disease in both hemodialysis and renal transplantation patients. Although lipid profiles differ between the 2 populations, we evaluated the possibility that both groups have similar abnormalities of lipoprotein(a) [Lp(a)]. Mean serum Lp(a) and standard error of the mean (SEM) in hemodialysis and transplant recipients was 16.6 +/- 4.7 and 18.3 +/- 3.6 mg/dl, respectively, compared with 10.7 +/- 4.1 mg/dl in healthy controls, p less than 0.05. That serum Lp(a) levels are significantly elevated in dialysis and renal transplantation patients suggests at least 1 common pathogenic mechanism for the high incidence of atherosclerosis in both groups.
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