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  • Title: Factors predictive of outcome in posttraumatic seizures.
    Author: Wang HC, Chang WN, Chang HW, Ho JT, Yang TM, Lin WC, Chuang YC, Lu CH.
    Journal: J Trauma; 2008 Apr; 64(4):883-8. PubMed ID: 18404052.
    Abstract:
    BACKGROUND: Seizures are important neurologic complications of traumatic brain injury (TBI). There is a need for better delineation of potential prognostic factors and outcomes in patients with posttraumatic seizures (PTS) who could receive treatment when brought to the hospital. METHODS: In this 10-year retrospective study, 170 adult patients with PTS were enrolled in this study. The degree of seizure control was analyzed using a Seizure Frequency Scoring System, which classified them into excellent and nonexcellent outcomes. RESULTS: There were 170 patients with acute symptomatic seizure enrolled in this study, 106 of whom had early PTS, whereas 64 had late PTS. Of the 106 early PTS, 58% (61 of 106) occurred within 24 hours of trauma. Risk factors for developing nonexcellent outcome included patients who undergo surgical intervention and presence of late-provoked seizures during the acute phase of TBI. CONCLUSIONS: Seizures are an important neurologic complication of TBI. Regarding the potentially side effects of antiepileptic drugs, antiepileptic therapy should be carefully administrated in those nonexcellent outcome patients.
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