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  • Title: Protective effects of phenolic fraction of blue honeysuckle fruits against UVA-induced damage to human keratinocytes.
    Author: Svobodová A, Rambousková J, Walterová D, Vostálová J.
    Journal: Arch Dermatol Res; 2008 Jun; 300(5):225-33. PubMed ID: 18404271.
    Abstract:
    In this study, the UVA (photo)protective activity of the phenolic fraction of L. caerulea fruits (PFLC) was assessed in human keratinocytes HaCaT. The keratinocytes were pre- or post-treated with PFLC (1-250 mg/l) and exposed to UVA irradiation (10-30 J/cm(2)). The results showed that both pre- and post-treatment with PFLC significantly suppressed UVA-induced ROS production, which was also revealed as a decrease in intracellular lipid peroxidation and elevation of reduced glutathione. Protection was concentration-dependent with a maximum at 50 mg/l. These results suggest that PFLC attenuates UVA-induced oxidative stress by reduction of ROS generation and ROS-mediated damage. For this reason, PFLC has potentially skin-protective functions against the deleterious effects of sunlight.
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