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  • Title: Antitubercular triterpenes and phytosterols from Pandanus tectorius Soland. var. laevis.
    Author: Tan MA, Takayama H, Aimi N, Kitajima M, Franzblau SG, Nonato MG.
    Journal: J Nat Med; 2008 Apr; 62(2):232-5. PubMed ID: 18404330.
    Abstract:
    Bioassay-guided chromatographic purification of the antitubercular chloroform extract of Pandanus tectorius Soland. var. laevis leaves afforded a new tirucallane-type triterpene, 24,24-dimethyl-5 beta-tirucall-9(11),25-dien-3-one (1), squalene and a mixture of the phytosterols stigmasterol and beta-sitosterol. Microplate Alamar Blue Assay (MABA) showed that 1 inhibited the growth of Mycobacterium tuberculosis H(37)Rv with a MIC of 64 microg/mL, while squalene and the sterol mixture have MICs of 100 and 128 microg/mL, respectively.
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