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  • Title: Synthesis, cytotoxicity and protein kinase C inhibition of arylpyrrolylmaleimides.
    Author: Xu GQ, Zhang C, Zhang L, Zhou XL, Yang B, He QJ, Hu YZ.
    Journal: Arch Pharm (Weinheim); 2008 May; 341(5):273-80. PubMed ID: 18404777.
    Abstract:
    A series of novel arylpyrrolylmaleimides was synthesized and evaluated for their in-vitro cytotoxicity against various human cancer cell lines and their protein-kinase C inhibitory activity. Some of the compounds showed high or moderate cytotoxic activity against the tested cell lines. Compound 6b is the most promising compound against the tested cancer cell lines; 6d and 6e showed moderate protein-kinase C inhibition. Structure-activity relationships are discussed based on the experimental data obtained.
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