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  • Title: West syndrome with periventricular leukomalacia: ten-year clinical study.
    Author: Kuzmanić-Samija R, Resić B, Tomasović M, Gabrić Pandurić D, Lozić B, Lozić M, Resić J.
    Journal: Coll Antropol; 2008 Jan; 32 Suppl 1():105-11. PubMed ID: 18405067.
    Abstract:
    The aim of the study was to evaluate magnetic resonance imaging (MRI) findings in infants with periventricular leukomalacia (PVL) and West syndrome (WS) and determine the neurodevelopmental outcome in children with West syndrome and PVL. Ultrasound and brain MRI were performed in 37 infants with recognized PVL. PVL was categorized according to De Vries, whereas West syndrome was categorized according to International League Against Epilepsy 1989. West syndrome in our patients developed during the first 2 years of life. The most common interictal abnormality was hypsarrhythmia. All, except two patients had delayed development and various degrees of mental retardation. The most characteristic neuroimaging findings were major reduction in cerebral cortical gray matter volume, reduction in the volume of brain myelin, and delayed myelination. These findings may explain the anatomical association between the West syndrome onset and PVL and intellectual and cognitive deficit in premature infants with PVL.
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