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  • Title: Genetic analysis of a meiotic recombination hotspot on chromosome III of Saccharomyces cerevisiae.
    Author: Symington LS, Brown A, Oliver SG, Greenwell P, Petes TD.
    Journal: Genetics; 1991 Aug; 128(4):717-27. PubMed ID: 1840557.
    Abstract:
    In a previous study, we analyzed meiotic recombination events that occurred in the 22-kb region (LEU2 to CEN3) of chromosome III of Saccharomyces cerevisiae. We found one region with an enhanced level of crossovers (a hotspot) and one region with a depressed level of crossovers. In this study, we show that about one-third of the crossovers that occur between LEU2 and CEN3 are initiated in a 1.3-kb region located approximately 6 kb from the centromere. Both crossovers and gene conversion events are initiated at this site. Events initiated at this position can be resolved as crossovers in regions located either centromere-distally or centromere-proximally from the initiation site.
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