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  • Title: Osteoblastic cells: differentiation and trans-differentiation.
    Author: Kassem M, Abdallah BM, Saeed H.
    Journal: Arch Biochem Biophys; 2008 May 15; 473(2):183-7. PubMed ID: 18406334.
    Abstract:
    The osteoblast is the bone forming cell and is derived from mesenchymal stem cells (MSC) present among the bone marrow stroma. MSC are capable of multi-lineage differentiation into mesoderm-type cells such as osteoblasts and adipocytes. Understanding the mechanisms underlying osteoblast differentiation from MSC is a central topic in bone biology that can provide insight into mechanisms of bone maintenance and also novel pharmacological targets to increase osteoblast differentiation and consequently bone formation.
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