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  • Title: Solid-phase synthesis of azidomethylene inhibitors targeting cysteine proteases.
    Author: Yang PY, Wu H, Lee MY, Xu A, Srinivasan R, Yao SQ.
    Journal: Org Lett; 2008 May 15; 10(10):1881-4. PubMed ID: 18407644.
    Abstract:
    An efficient strategy for the solid-phase synthesis of azidomethylene inhibitors targeting cysteine proteases is described. The method is highlighted by its compatibility with readily available building blocks, as well as its ability to accommodate different functional groups. A 249-member library has thus far been successfully synthesized, characterized, and screened against Caspase-1, -3 and -7.
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