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  • Title: Synthesis of DAAS derivatives and their enhancement of HL-60 leukemia cell differentiation.
    Author: Kim SH, Chung SY, Kim YW, Kim TS, Choi BG.
    Journal: Arch Pharm Res; 2008 Mar; 31(3):300-4. PubMed ID: 18409041.
    Abstract:
    DAAS is the diacetoxy acetal derivative of a-santonin and induces HL-60 cell differentiation into granulocytes. In this report, we investigated the structure-activity relationship (SAR) of DAAS derivatives in the differentiation of human HL-60 leukemia cells. Although its derivatives themselves had less effect on HL-60 cell differentiation than DAAS, the monoacetyl derivative, 2, mainly induced HL-60 cell differentiation. Moreover, compound 2 synergistically enhanced all-trans retinoic acid (ATRA)-induced HL-60 cell differentiation when combined with 50 nM ATRA, a well-known differentiation inducer. This enhancing effect is similar to that of DAAS in ATRA-induced differentiation.
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