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  • Title: [Signal pathway of insulin and insulin-like growth factor 1 (IGF-1) as a potential regulator of lifespan].
    Author: Chistiakova OV.
    Journal: Zh Evol Biokhim Fiziol; 2008; 44(1):3-11. PubMed ID: 18411507.
    Abstract:
    The experimental material accumulated for two decades allows concluding that regulation of lifespan has hormonal control based on the evolutionary conservative insulin/IGF-1 receptor signal pathway. Data obtained on the commonly accepted models of longevity - nematode Caenorhabditis elegans, Drosophila Drosophila melanogaster, and rodents - demonstrate that reduction of the insulin/IGF- 1 signal pathway leads to an increase of the lifespan. There is shown involvement of the longevity mechanism of a large group of genes whose products perform control of metabolism, alimentary behavior, reproduction, resistance to oxidative stress. Discussed in this review are current concepts of the insulin/IGF-1 signal system as a regulatory "longevity module" and of its possible role in prolongation of life in the higher vertebrates, including human.
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