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  • Title: Diagnostic test evaluation of a nasal flow monitor for obstructive sleep apnea detection in sleep apnea research.
    Author: Wong KK, Jankelson D, Reid A, Unger G, Dungan G, Hedner JA, Grunstein RR.
    Journal: Behav Res Methods; 2008 Feb; 40(1):360-6. PubMed ID: 18411561.
    Abstract:
    In this diagnostic test evaluation of a nasal flow monitoring device for obstructive sleep apnea (OSA), 34 patients referred for polysomnography were studied at home for three consecutive nights with the monitor. The mean age of subjects (+/-SD) was 41.9+/-10.3 years, and their mean apnea-hypopnea index (AHI) was 31.5+/-27.2. The difference between the average AHI from three nights at home on the monitor and the polysomnogram (PSG) result was 1.8+/-17.1. The area under the receiver operating characteristic curve (AUC) for PSG AHI > or = 10 was .96. With a threshold AHI of 18 on the flow monitor, sensitivity was .92, specificity .86, positive predictive value .96, and negative predictive value .75. For detecting severe OSA (AHI > or = 30), the AUC was .85. With knowledge of appropriate thresholds and the pretest risk of OSA, the flow monitor can be used to detect or exclude OSA for sleep-related research, as well as to identify severe cases needing priority for further evaluation.
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