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  • Title: Polymorphisms of the XRCC1 and XPD genes and breast cancer risk: a case-control study.
    Author: Kipikasová L, Wolaschka T, Bohus P, Baumohlová H, Bober J, Blazejová J, Mirossay L, Sarisský M, Mirossay A, Cizmáriková M, Potoceková D, Mojzis J.
    Journal: Pathol Oncol Res; 2008 Jun; 14(2):131-5. PubMed ID: 18415712.
    Abstract:
    The purpose of this case control study was to evaluate the role of X-ray repair cross-complementing group 1 (XRCC1) and xeroderma pigmentosum group D (XPD) genotypes as genetic indicators of susceptibility to breast cancer (BC). We analysed DNA samples from 114 breast cancer patients and 113 control subjects using polymerase chain reaction-restriction fragment length polymorphism. For the single nucleotide polymorphisms in XRCC1 exon 10 (Arg399Gln, G/A) and XPD exon 23 (Lys751Gln, A/C), no remarkable differences for genotype distribution and allele frequencies were observed between BC group and control group in the study. The genotype frequency for homozygote A/A in XPD exon 6 (Arg156Arg, C/A) were significantly different between BC and control groups (P < 0.0001, odds ratio = 2.14; 95% confidence interval 1.44-3.17). The data indicate a possible role for XPD (Arg156Arg, C/A) polymorphisms in BC susceptibility.
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