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  • Title: [Research on relationship between angiotensinogen gene M235T and TCM syndrome type in essential hypertension patients].
    Author: Wan YX, Zhang TZ.
    Journal: Zhongguo Zhong Xi Yi Jie He Za Zhi; 2008 Jan; 28(1):36-8. PubMed ID: 18418967.
    Abstract:
    OBJECTIVE: To explore the relationship between angiotensinogen (AGT) gene M235T and TCM syndrome type in essential hypertension (ET) patients. METHODS: The gene mutation frequency of AGT M235T in 168 ET patients and 42 nomotensive (NT) subjects were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. RESULTS: There was a significant difference in AGT M235T gene mutation between patients of Gan-fire exuberant type and those of yin-yang deficiency type (P < 0.01), homozygote type TT appeared with higher frequency. Multivariate regression linear analysis demonstrated that the genotypes of AGT M235T was correlated with the prognosis of ET to a certain degree. CONCLUSION: Gene mutation of AGT M235T may be associated with the genesis and development of ET, and the TCM syndrome type of ET has its own intrinsic molecular biological background.
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