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  • Title: Efficient synthesis of 3-iodoindenes via Lewis-acid catalyzed Friedel-Crafts cyclization of iodinated allylic alcohols.
    Author: Zhou X, Zhang H, Xie X, Li Y.
    Journal: J Org Chem; 2008 May 16; 73(10):3958-60. PubMed ID: 18419158.
    Abstract:
    A convenient BF(3).Et(2)O-catalyzed Friedel-Crafts cyclization of iodinated allylic alcohols is reported. The present reaction provides an efficient protocol to 3-iodo-1(H)-indene derivatives in good to high yields under mild conditions. Further, the iodoindene derivatives are valuable synthetic building blocks for elaboration of molecular complexity, such as in the construction of multiaryl substituted indenes by Suzuki coupling reaction.
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