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  • Title: Effects of follicle-stimulating hormone and luteinizing hormone on ovarian cyclic AMP and prostaglandin E in vivo in rats treated with indomethacin.
    Author: Rigler GL, Peake GT, Ratner A.
    Journal: J Endocrinol; 1976 Aug; 70(2):285-91. PubMed ID: 184230.
    Abstract:
    The role of prostaglandins in both FSH- and LH-mediated increases in ovarian cyclic AMP was examined in rats in vivo. Dose-related increases in ovarian cyclic AMP levels were observed 10 min after intravenous injection of FSH or LH. No changes in ovarian prostaglandin E (PGE) content were detected after injection of either gonadotrophin at doses which substantially enhanced cyclic AMP accumulation. Prior treatment of rats with indomethacin produced a greater than 50% decrease in ovarian PGE levels, but did not prevent the FSH- or LH-induced rise in ovarian cyclic AMP concentration. These in vivo experiments do not support the concept that PGE plays a role as an obligatory mediator for the gonadotrophin-induced rise in ovarian cyclic AMP levels.
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