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  • Title: Regulation of cdc2 activity in Schizosaccharomyces pombe: the role of phosphorylation.
    Author: Fleig UN, Gould KL.
    Journal: Semin Cell Biol; 1991 Aug; 2(4):195-204. PubMed ID: 1842338.
    Abstract:
    The cdc2 protein kinase, first identified as a cell cycle gene required for transition into the S- and M-phases of budding and fission yeast, has been shown to act as a key component in the regulation of the eukaryotic cell cycle. The periodic activation of cdc2 kinase, which is required for entry into M-phase, is regulated by subunit association with cyclin B, the cdc25, wee1, mik1 gene products and differential phosphorylation of the cdc2 protein. Phosphorylation at Tyr 15 inhibits activation of the cdc2/cdc13 complex whereas phosphorylation of Thr 167 is required for kinase activity.
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