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  • Title: E-cadherin expression in canine cutaneous histiocytomas.
    Author: Baines SJ, McInnes EF, McConnell I.
    Journal: Vet Rec; 2008 Apr 19; 162(16):509-13. PubMed ID: 18424847.
    Abstract:
    Canine cutaneous histiocytoma is a common skin tumour of Langerhans cell origin. Langerhans cells are members of the dendritic cell family of antigen-presenting cells and are located in the epidermis. They are unique among the dendritic cell lineage in that they express high levels of the adhesion molecule E-cadherin. The expression of E-cadherin by the neoplastic Langerhans cells in 37 dogs with cutaneous histiocytoma was studied by flow cytometry and immunohistochemistry. In all the cases, these cells expressed E-cadherin, whereas the infiltrating lymphocytes did not.
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