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  • Title: [Endogenous risk factors for bladder neoplasms in women].
    Author: Prianichnikova MB.
    Journal: Vopr Onkol; 1991; 37(9-10):925-9. PubMed ID: 1842651.
    Abstract:
    A case-control study was performed to evaluate hormonal status in 154 female patients with bladder cancer and 213 healthy women. Cancer patients were characterized by shorter reproductive period and miscarriage, absence of gestation, endometrial and breast cancer and ovarian cysts in the past history. Evaluation of tryptophan metabolism in 131 male and 111 female patients with bladder cancer showed the occurrence of a carcinogenic metabolite--3-oxyanthranilic acid--in the urine to be higher in women. Blood hormone levels were measured in 55 female patients and 49 healthy women by radioimmunoassay. Decreased levels of progesterone and estradiol as well as of hormones potentiating their production (folitropin and lutropin) were the most frequent hormonal disorders encountered.
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