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  • Title: The IL-6 system in HIV-1-infection and in HAART-related fat redistribution syndromes.
    Author: Saumoy M, López-Dupla M, Veloso S, Alonso-Villaverde C, Domingo P, Broch M, Miranda M, Coll B, Saurí A, Vendrell J, Richart C, Vidal F.
    Journal: AIDS; 2008 Apr 23; 22(7):893-6. PubMed ID: 18427208.
    Abstract:
    We determined the IL-6 -174 G>C single nucleotide polymorphism, IL-6 mRNA expression in subcutaneous adipose tissue (SAT) and IL-6 plasma levels in HIV-1-infected patients with and without lipodystrophy and uninfected controls. HIV-1-infected patients had a greater prevalence of the IL-6 -174 C/C genotype and the C allele, higher SAT IL-6 mRNA expression and plasma IL-6 levels than controls. The IL-6 -174 G>C genotype distribution and allele frequencies, SAT IL-6 mRNA expression and IL-6 plasma levels were non-significantly different between HIV-1-infected patients with and without lipodystrophy.
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