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  • Title: Effect of normal human erythrocytes on blood rheology in microcirculation.
    Author: Hirata C, Kobayashi H, Mizuno N, Kutsuna H, Ishina K, Ishii M.
    Journal: Osaka City Med J; 2007 Dec; 53(2):73-85. PubMed ID: 18432063.
    Abstract:
    BACKGROUND: Effects of RBCs on blood rheology were studied using a microchannel array flow analyzer (MC-FAN). METHODS: Fluidity of four types of samples prepared from the venous blood of healthy volunteers was examined in terms of passage time through the microchannel array of MC-FAN (model KH-3): (1) physiological saline-RBC suspensions and plasma-RBC suspensions, each adjusted to a predetermined hematocrit value; (2) suspensions of glutaraldehyde-treated hardened RBCs; (3) fibrinogen-RBC and albumin-RBC suspensions; and (4) dextran-RBC suspensions. RESULTS: Hematocrit positively correlated with passage time. Both plasma and fibrinogen prolonged passage time significantly. Hardened RBCs completely obstructed the microchannel. The passage time of dextran-RBC suspensions was prolonged in a dextran molecular weight- and concentration-dependent manner and was dependent on the passage time of the solution alone. CONCLUSIONS: Blood rheology, as determined by MC-FAN, is affected not by RBC aggregation but hematocrit, RBC deformability, and the passage time of the solution.
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