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  • Title: [Application of modified ultrafiltration in infants undergoing cardiac surgery with cardiopulmonary bypass].
    Author: Cheng W, Xiao YB, Zhong QJ.
    Journal: Zhongguo Dang Dai Er Ke Za Zhi; 2008 Apr; 10(2):152-4. PubMed ID: 18433534.
    Abstract:
    OBJECTIVE: Infants are usually subjected to serious complications after cardiac surgery with cardiopulmonary bypass (CPB). This study was conducted to evaluate the effects of a modified ultrafiltration technique (MUF) on infants undergoing cardiac surgery with CPB. METHODS: A total of 261 infants less than 1 year old with congenital heart disease and who required CPB were randomized into receive MUF during CPB (n=205) or not (n=56, control group). Bypass duration, aortic cross-clamp duration, postoperative blood effluents and transfusions, mechanical ventilation duration following operation, and hematocrit and oxygenation index 24 hrs postoperatively were compared between the two groups. RESULTS: No ultrafiltration-related complication was found in the MUF group. There were no significant differences in the duration of bypass and aortic cross-clamp between the two groups. Postoperative blood effluents and transfusions in the MFU group were significantly reduced (79.5+/-18.6 mL vs 57.3+/-15.4 mL and 78.1+/-32.5 mL vs 67.9+/-25.6 mL respectively) compared with the control group (P<0.05). The duration of mechanical ventilation following operation in the MFU group was shorter than that in the control group (28.6 +/- 9.1 hrs vs 32.3 +/- 8.7 hrs; P<0.05). MUF produced a significant improvement in hematocrit (34.6 +/- 3.7 min vs 29.8+/-2.8 min; P<0.01) and oxygenation index (275.2+/-39.1 vs 202.2+/-25.6; P<0.01) 24 hrs postoperatively when compared with the control group. CONCLUSIONS: MFU can reduce postoperative bleeding and blood transfusions, improve pulmonary function and shorten the duration of mechanical ventilation in infants undergoing cardiac surgery with CPB.
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