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  • Title: Atovaquone-proguanil resistance in imported falciparum malaria in a young child.
    Author: Rose GW, Suh KN, Kain KC, Le Saux N, McCarthy AE.
    Journal: Pediatr Infect Dis J; 2008 Jun; 27(6):567-9. PubMed ID: 18434932.
    Abstract:
    We discuss a case of atovaquone-proguanil treatment failure in a child from Mozambique, recently arrived in North America. Four weeks after completing therapy, symptomatic parasitemia recurred, caused by Plasmodium falciparum parasites bearing a Tyr268Ser mutation in cytochrome b. We review the literature concerning atovaquone-proguanil resistance, and emphasize the importance of follow-up and consideration of resistance where patients have relapsed symptoms.
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