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  • Title: Base-catalyzed intramolecular hydroamination of conjugated enynes.
    Author: Zhang W, Werness JB, Tang W.
    Journal: Org Lett; 2008 May 15; 10(10):2023-6. PubMed ID: 18435544.
    Abstract:
    A de novo intramolecular hydroamination of conjugated enynes was developed using commercially available n-BuLi as a precatalyst. This hydroamination reaction successfully afforded allenyl-substituted pyrrolidines with up to 95% yield. One of the resulting allenyl pyrrolidines was converted to the natural products irniine and irnidine in three steps.
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