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  • Title: Deaminated UV filter 3-hydroxykynurenine O-beta-D-glucoside is found in cataractous human lenses.
    Author: Snytnikova OA, Fursova AZh, Chernyak EI, Vasiliev VG, Morozov SV, Kolosova NG, Tsentalovich YP.
    Journal: Exp Eye Res; 2008 Jun; 86(6):951-6. PubMed ID: 18436210.
    Abstract:
    Analysis of UV filter levels in 48 cataractous human lenses was performed with the use of HPLC. A new chromophore with the absorption maximum at 410nm and molecular mass of 369Da was detected and assigned as deaminated 3-hydroxykynurenine O-beta-D-glucoside (3OHCKAG). Cataractous lenses are characterized by the wide range of the UV filter concentrations and remarkably lower levels of UV filters and glutathione than published for the normal lenses. No correlation between the lens age and the level of UV filters has been found in cataractous lenses.
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