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  • Title: Extended release carbamazepine in the treatment of pathological gambling: an open-label study.
    Author: Black DW, Shaw MC, Allen J.
    Journal: Prog Neuropsychopharmacol Biol Psychiatry; 2008 Jul 01; 32(5):1191-4. PubMed ID: 18436362.
    Abstract:
    BACKGROUND: The efficacy and tolerability of extended release carbamazepine was tested in the treatment of pathological gambling (PG). METHOD: Non-depressed outpatients with DSM-IV PG received flexibly dosed extended release carbamazepine in a prospective 10-week open-label trial following a two-week observation period. Subjects were evaluated at baseline and at one week intervals during a four week titration period, and every two weeks thereafter for assessment of gambling behavior, mood, and adverse experiences. The primary efficacy measure was the Yale-Brown Obsessive-Compulsive Scale modified for PG (YBOCS-PG). RESULTS: Eight subjects (6 men, 2 women) had at least one post-baseline visit, and five subjects (63%) completed the protocol. Significant improvement was found on the YBOCS-PG (P< .001). Seven of the eight subjects with post-baseline assessment (88%) were considered responders (i.e., achieved "much" or "very much" improvement on the CGI). Four subjects (50%) abstained from gambling during their final month of study participation. Several patients were dropped because of adverse experiences. CONCLUSION: The results suggest that extended release carbamazepine may be effective in the treatment of PG.
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