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  • Title: [Effect of pirenzepine, a selective M1 muscarinic receptor antagonist, on the bronchial tree patency in patients with bronchial asthma].
    Author: Siergiejko Z, Rutkowski R, Chyrek-Borowska S.
    Journal: Pneumonol Alergol Pol; 1991; 59(3-4):96-101. PubMed ID: 1843915.
    Abstract:
    The effect of a single intravenous dose of pirenzepine on ventilatory indices of 22 asthmatics was studied. The following were assessed: FVC, FEV1, FEF50, FEF25-75, Raw, heart rate (HR) prior administration and after 5, 15, 30, 60, 120, and 180 minutes after receiving 10 mg of pirenzepine. A statistical significant decrease of airflow resistance was seen in control and mild asthmatics (lowering of Raw, FEF25-75). Also an increase of FEV1 was seen in both asthmatic groups. In all patients a decrease of HR was seen.
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