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  • Title: Chronic otitis media and immunoglobulin E-mediated hypersensitivity in adults: is it a contributor of cholesteatoma?
    Author: Hong SD, Cho YS, Hong SH, Chung WH, Chung KW.
    Journal: Otolaryngol Head Neck Surg; 2008 May; 138(5):637-40. PubMed ID: 18439471.
    Abstract:
    OBJECTIVES: The aim of this study was to determine the relationship between chronic otitis media (COM) and immunoglobulin E (IgE)-mediated hypersensitivity in adults. STUDY DESIGN: A prospective comparative study. SUBJECTS AND METHODS: One hundred seventeen patients with COM from July 2005 to April 2007 were enrolled. All subjects had a questionnaire on allergic rhinitis symptoms and performed allergy tests that included a total IgE and the multiple radioallergosorbent chemiluminescence assay to check the presence of IgE-mediated hypersensitivity. RESULTS: The prevalence of IgE-mediated hypersensitivity and allergic rhinitis were 22.2% and 7.7% in patients with COM, respectively. The mean total IgE was 157.2 ranging from 3 to 1833. The prevalence of IgE-mediated hypersensitivity was similar with regard to the recurrence or bilaterality. However, patients with cholesteatoma had a higher prevalence of IgE-mediated hypersensitivity than patients without that condition. CONCLUSION: The prevalence of IgE-mediated hypersensitivity and allergic rhinitis in adults with COM appeared to be higher than in the general population. Allergy might contribute to COM especially in cases with a cholesteatoma.
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