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  • Title: Corpus callosotomy in a patient of hemimegalencephaly and Lennox-Gastaut syndrome.
    Author: Kwan SY, Shyu HY, Lin JH, Wong TT, Chang KP, Yiu CH.
    Journal: Brain Dev; 2008 Nov; 30(10):643-6. PubMed ID: 18439776.
    Abstract:
    We report the case of a girl with hemimegalencephaly (HME) and Lennox-Gastaut syndrome (LGS) treated by callosotomy at 1 year of age. Over 10 years, her seizure frequency and severity decreased markedly. Hemispherectomy is the main surgical option for HME although HME appears to correlate with a less favorable seizure outcome. However, the clinical presentation of LGS and possible generalized cortical dysplasia, which is indicative of a secondarily generalized epilepsy, might predict a favorable surgical outcome of corpus callosotomy in patients of HME, as in our case.
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