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  • Title: Polycomb complexes and epigenetic states.
    Author: Schwartz YB, Pirrotta V.
    Journal: Curr Opin Cell Biol; 2008 Jun; 20(3):266-73. PubMed ID: 18439810.
    Abstract:
    Important advances in the study of Polycomb Group (PcG) complexes in the past two years have focused on the role of this repressive system in programing the genome. Genome-wide analyses have shown that PcG mechanisms control a large number of genes regulating many cellular functions and all developmental pathways. Current evidence shows that, contrary to the classical picture of their role, PcG complexes do not set a repressed chromatin state that is maintained throughout development but have a much more dynamic role. PcG target genes can become repressed or be reactivated or exist in intermediate states. What controls the balance between repression and derepression is a crucial question in understanding development and differentiation in higher organisms.
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