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  • Title: [Neurochemical disturbances in the rat's body due to combined action of pirimicarb and thiram. Part II: Changes in levels of catecholamines and serotonin in rat brain, heart and adrenal glands after different doses].
    Author: Biel-Zielińska A, Brzeziński J.
    Journal: Rocz Panstw Zakl Hig; 1991; 42(4):437-43. PubMed ID: 1844019.
    Abstract:
    Investigation was made of the effect exerted on the dynamic equilibrium of catecholamines and serotonin in rat brain, heart and adrenal glands by an equitoxic mixture of pirimicarb/thiram (under conditions of subacute poisoning, per os with a dose amounting to 20% of LD50), as well as by pirimicarb and a pirimicarb/thiram mixture (under conditions of multiple short-term (14 days) poisoning, per os with a dose amounting to 5% of DL50). It was shown that an equitoxic mixture of pirimicarb/thiram caused upon acute poisoning disturbances in the levels of the investigated amine these changes were strongly expressed than in the case of pirimicarb itself, and their direction agreed with that found for acute poisoning with 50% DL50. In multiple short-term poisoning, pirimicarb itself slightly activated only the serotoninergic system in the heart. Under these conditions an equitoxic mixture of pirimicarb and thiram, as compared with pirimicarb itself, displayed considerable activity towards the system of the investigated amines. Thus, thiram applied in an equitoxic mixture pirimicarb evidently intensifies and prolongs the neurochemical effect of pirimicarb in rat.
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