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  • Title: Inexpensive anti-cysticercosis vaccine: S3Pvac expressed in heat inactivated M13 filamentous phage proves effective against naturally acquired Taenia solium porcine cysticercosis.
    Author: Morales J, Martínez JJ, Manoutcharian K, Hernández M, Fleury A, Gevorkian G, Acero G, Blancas A, Toledo A, Cervantes J, Maza V, Quet F, Bonnabau H, de Aluja AS, Fragoso G, Larralde C, Sciutto E.
    Journal: Vaccine; 2008 Jun 02; 26(23):2899-905. PubMed ID: 18440675.
    Abstract:
    In search of reducing vaccine production costs', a recombinant M13 phage version of the anti-cysticercosis tripeptide vaccine (S3Pvac) was developed. The efficacy of S3Pvac-Phage vs. placebo was evaluated in a randomized trial that included 1,047 rural pigs in 16 villages of Central Mexico. Three to five months after vaccination 530 pigs were examined by tongue inspection. At 5-27 months of age, 331 pigs (197 vaccinated/134 controls) were inspected at necropsy. Vaccination reduced 70% the frequency of tongue cysticercosis and, based on necropsy, 54% of muscle-cysticercosis and by 87% the number of cysticerci.
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